Research Assistant Professor

PHONE: (757) 683-7027

EMAIL: isemenov@odu.edu, iurii.semenov@gmail.com

ADDRESS: IRP 2, 4211 Monarch Way, Norfolk, VA, 23508

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Education

• Postdoctoral Research fellow:

  2003 - 2006: Postdoctoral Fellow, Department of Physiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr., San Antonio TX 78229, USA

  2006 - 2008: Postdoctoral Fellow, Department of Biochemistry, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr., San Antonio TX 78229, USA

  2008 - 2009: Visiting Research Specialist, Department of Medicine, Section of Cardiology, University of Illinois at Chicago, 840 S. Wood St., Chicago, IL 60612, USA

  2009 - 2011: Postdoctoral Researcher, Department of Physiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr., San Antonio TX 78229, USA

  2012 - 2013: Postdoctoral Researcher, Frank Reidy Research Center for Bioelectrics, Old Dominion University 4211 Monarch Way, Suite 318, Norfolk, VA 23508

• PhD: Taras Shevchenko Kyiv National University, Biological Faculty. Volodymyrska Str. 64, Kyiv, Ukraine, 01033, 2002
• M.S: Taras Shevchenko Kyiv National University, Biological Faculty. Volodymyrska Str. 64, Kyiv, Ukraine, 01033, 1996

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Research Description

My research interests are focused on intracellular effects of nanosecond pulsed electric fields (nsPEFs), particularly on how function of the cells of different types can be manipulated using nsPEFs. I also investigate nsPEF effects on molecular mechanisms of intracellular calcium regulation and signal-transduction pathways in the excitable and non-excitable cells. Our team revealed that nanosecond stimuli can mimic natural Ca2+ signaling while bypassing the usual receptor- and channels-mediated cascades. The recruitment of the intracellular Ca2+ can be controlled by the duration of the stimulus. We also reported a novel phenomenon of bioeffects cancellation observed when secondary nanosecond pulse of the same strength and duration, but opposite polarity, follows closely after the first pulse. It puts nanosecond electric pulses apart from the conventional electroporation and electrostimulation by milli- and microsecond pulses.

I work in tight collaboration with Prof. Pakhomov and take a part in the projects devoted to bipolar cancellation and nsPEF defibrillation of a heart. These research efforts are supported by MURI grant from AFOSR, an RO1 grant from NIH.

Most relevant publications

1. Pakhomov A, Gudvangen E, Xiao S, Semenov I. Interference targeting of bipolar nanosecond electric pulses for spatially focused electroporation, electrostimulation, and tissue ablation. Bioelectrochemistry. 2021 Jun 15;141:107876. doi: 10.1016/j.bioelechem.2021.107876.
2. Semenov I, Grigoryev S, Neuber JU, Zemlin CW, Pakhomova ON, Casciola M, Pakhomov AG. Excitation and injury of adult ventricular cardiomyocytes by nano- to millisecond electric shocks. Sci Rep. 2018 May 29;8(1):8233. doi: 10.1038/s41598-018-26521-2.
3. Semenov I, Xiao S, Kang D, Schoenbach KH, Pakhomov AG Cell stimulation and calcium mobilization of by picosecond electric pulses. Bioelectrochemistry. 2015 Oct;105:65-71.
4. Semenov I, Xiao S, Pakhomova ON, Pakhomov AG. Recruitment of the intracellular Ca2+ by ultrashort electric stimuli: the impact of pulse duration. Cell Calcium. 2013 Sep;54(3):145-50. doi: 10.1016/j.ceca.2013.05.008. Epub 2013 Jun 15.
5. Semenov I, Xiao S, Pakhomov AG. Primary pathways of intracellular Ca(2+) mobilization by nanosecond pulsed electric field. Biochim Biophys Acta. 2013 Mar;1828(3):981-9. doi: 10.1016/j.bbamem.2012.11.032. Epub 2012 Dec 5.