Jennifer Poutsma

Associate Professor
Chemistry & Biochemistry

Contact Information

CHEMISTRY BUILDING 4501 ELKHORN AVE
NORFOLK, VA 23529

Email: jradkiew@odu.edu

Phone: 757-683-4101

Education/Credentials

Web Link(s)

www.odu.edu/~jradkiew/

Expertise

Computational Chemistry

Physical Organic Chemistry
Research Interests

Dr. Poutsma’s group focuses on the application of computational chemistry to problems in organic, inorganic and biochemistry. Currently, the organic projects involve calculating the proton affinities of peptides, the mechanisms of mass spectrometry fragmentation and the mechanisms of peptide hydrogen/deuterium exchange. The goal of these projects is to expand our understanding of peptide fragmentation in order to improve the software used to predict protein sequence from mass spectrometry data. <br> <br>The inorganic project involves calculating the mechanisms of small aluminumoxide clusters with methane. The biochemistry projects focus on protein folding and are in conjunction with Dr. Lesley Greene of ODU.

Articles

Arrington, J. V., Straus, R., Reynolds, P. F., Poutsma, J. L., Marluff, E. M., and Poutsma, J. C. (2012). Gas-Phase Hydrogen Deuterium Exchange of Lysine Homologs. Int. J. Mass Spectrom, 330-332, pp. 200-206.

Ribelin, T., Katz, C. E., English, D., Smith, S., Manukyan, A. K., Day, A. K., Neuenswander, B., Poutsma, J. L., and Aube, J. (2008). Highly Stereoselective Ring Expansion Reactions Mediated by Attractive, Non-Bonded Cation-Interactions. Angew. Chem. Int. Ed., 47, pp. 6233-6235.

Katz, C. E., Ribelin, T., Withrow, D., Basseri, Y., Manukyan, A. K., Bermudez, A., Smith, S., Nuera, C. G., Day, V. W., Powell, D. R., Poutsma, J. L., and Aube, J. (2008). Non-Bonded, Attractive Cation-πInteractions in Azide-Mediated Asymmetric Ring Expansion Reactions. J. Org. Chem., 73, pp. 3318-3327.

Grecian, S., Desai, P., Mossman, C., Poutsma, J. L., and Aube, J. (2007). Reactions of Cyclopropanone Acetals with Alkyl Azides: Carbonyl Addition versus Ring-Opening Pathways. J. Org. Chem., 72, pp. 9439-9447.

Manukyan, A. K., and Poutsma, J. L. (2006). The Effect of Solvent on the Stereoselectivity of Reactions between Hydroxyalkyl Azides and Ketones. Theochem, 766, pp. 105-112.

Schroeder, O. E., Carper, E., Wind, J. J., Poutsma, J. L., Etzkorn, F., and Poutsma, J. C. (2006). Theoretical and Experimental Investigation of the Energetics of Cis-Trans Proline Isomerization in Peptide Models. J. Phys. Chem. A, 110, pp. 6522-6530.

LeTourneau, H., Birsch, R., Korbeck, G., and Poutsma, J. L. (2005). Study of the Dative Bond in 2-aminoethoxydiphenyl Borate at Vatious Levels of Theory: Another Poor Performance of the B3LYP method for B-N Dative Bonds. J. Phys. Chem. A, 109, pp. 12014-12019.

Hewlett, N. D., Aube, J., and Poutsma, J. L. (2004). Ab Initio Approach to Understanding the Stereoselectivity of Reactions between Hydroxyalkyl Azides and Ketones. J. Org. Chem., 69, pp. 3439-3446.

Snowden, M., Bermudez, A., Kelly, D. R., and Poutsma, J. L. (2004). The Preference for anti over gauche Migration in the Baeyer-Villiger Reaction. J. Org. Chem., 69, pp. 7148-7156.
Presentations

Arcoria, P., Poutsma, J. C., Wysocki, V. H., Somogyi, A., and Poutsma, J. L. (April, 2017). Gas-phase transition states of proline tripeptides Poster presented at ACS National Meeting San Francisco.

Kowalczyk, E., and Poutsma, J. L. (March 23, 2015). Why do Ala, Ala, Lys protonated tripeptides preferentially rearrange to the protonated Lys-Ala-Ala sequence in the gas phase? Oral Presentation presented at ACS National Meeting Denver, CO.

Poutsma, J. L. (October, 2013). The Use of Thermal Unfolding Molecular Dynamics Simulations to Study Protein Folding Virginia Commonwealth University.

Poutsma, J. L. (June, 2012). Failure of gas phase calculations to reproduce solvent experimental data in the Schmidt reaction Oral Presentation presented at Reaction Mechanisms Conference Columbia, Missouri.

Poutsma, J. L. (June, 2010). Mechanisms of the Schmidt Reaction with Various Azides and Solvent Effects Poster presented at Reaction Mechanism Conference Amherst, MA.

Poutsma, J. L. (August, 2009). Binding cooperativity in R67DHFR presented at 238th ACS National Meeting Washington, D.C..

Poutsma, J. L. (March, 2009). Molecular dynamics and structural studies of cyclopentane modified peptide nucleic acids presented at 237th ACS National Meeting Salt Lake City, UT.

Poutsma, J. L., and Shi, C. (August, 2008). Molecular dynamics simulations of R67 dihydrofolate reductase: Investigation into the cooperative binding presented at 236th ACS National Meeting Philadelphia, PA.

Poutsma, J. L. (June, 2008). The Use of Cation-π and Cation-n Interactions to Determine Stereoselectivity in Modified Schmidt Reactions presented at Houk65 Symposium Los Angeles, CA.

Poutsma, J. L., and Manukyan, A. K. (August, 2007). Molecular Dynamics Simulations of Peptide Nucleic Acids Modified with Cycloalkanes presented at 234th ACS National Meeting Boston, MA.

Schroeder, O. E., Carper, E., Wind, J. J., Poutsma, J. C., Etzkorn, F., and Poutsma, J. L. (July, 2006). Theoretical and Experimental Investigation of the Energetics of Cis-Trans Proline Isomerization in Peptide Models presented at Reaction Mechanism Conference College Park, MD.

Schroeder, O. E., Carper, E., Wind, J. J., Poutsma, J. C., Etzkorn, F., and Poutsma, J. L. (May, 2006). Theoretical and Experimental Investigation of the Energetics of Cis-Trans Proline Isomerization in Peptide Models presented at ASMS National Meeting Seattle, WA.

Poutsma, J. L. (June, 2005). Study of the Dative Bond in 2-Aminoethoxydiphenyl Borate at Various presented at Physical Organic Gordon Conference Holderness, NH.

Poutsma, J. L. (March, 2005). Ab Initio Study of the Stereoselectivity of Schmidt-Type Reactions presented at American Chemical Society National Meeting San Diego, CA.

Poutsma, J. L. (July, 2004). Reactions between Hydroxyalkyl Azides and Ketones presented at Organic Chemistry Workshop Greenlake, WI.

2015: Shining Star Recognition, Old Dominion University
2011: Shining Star Award, Old Dominion University
2009: Most Inspiring Faculty Award, Old Dominion University
1998: NRSA Postdoctoral Fellowship, NIH

Contracts, Grants and Sponsored Research

Poutsma, J. L. "Collaborative Research: Intrinsic Gas-phase Properties of Peptides: Thermochemistry, Fragmentation Mechanisms, H/D exchange and IRMPD Spectroscopy" $40,000. Federal. September 1, 2018 - August 31, 2021

Poutsma, J. L. "Collaborative Research: Gas Phase Properties of Non-Protein Amino Acids; Thermochemistry, H/D Exchange, and Peptide Fragmentation Studies" $30,042. Federal. September 1, 2015 - August 31, 2018

Poutsma, J. L. "Fragmentation Mechanisms, H/D exchange and IRMPD Spectroscopy of Non-Protein Amino Acids and Non-Protein Amino Acid-Containing Peptides" $45,654. Federal. September 1, 2015 - August 31, 2018

Poutsma, J. L. "Investigations of Dihydrofolate Reductases Using Molecular Dynamics Simulations" $185,262. Federal. March, 2006 - February, 2008

Poutsma, J. L. "Examination of the Mechanisms of the Schmidt and Modified-Schmidt Reactions" $80,000. Other. January, 2005 - August, 2007

Poutsma, J. L. "Investigations of Biological and Organic Systems Using Computational Methods" $303,900. Other. October, 2005 - September, 2006

Poutsma, J. L. "An Investigation of 2-Aminoethoxydiphenyl Borate and Analogs as Store-Operated Calcium Entry Channel Inhibitors" $10,000. State. January, 2003 - December, 2005

Poutsma, J. L. "The Mechanism and Source of Stereoselectivity for a Reaction between a Hydroxy Alkyl Azide and a Substituted Cyclohexanone" $25,000. Other. September, 2001 - September, 2003

Poutsma, J. L. "Investigation of the Loop Motions of Dihydrofalate Reductase" $5,000. Old Dominion University. June, 2001 - August, 2001

Old Dominion University

Idea Fusion

Jennifer Poutsma

Jennifer Poutsma

Contact Information

Organizational Chart

Education/Credentials

Web Link(s)

Expertise

Research Interests

Articles

Presentations

Contracts, Grants and Sponsored Research