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Michael Stacey

Michael Stacey


Contact Information

300 4211 MONARCH WAY

Email: mstacey@odu.edu

Phone: 757-683-2245



Web Link(s)

  • Expertise

    Biomedical sciences, Cell, Molecular Biology
  • Research Interests

    Research interests.For more detail, see the Mike Stacey's Homepage tab.A basis tenant of biology is that normal differentiated cells will respond to their environments. Chondrocytes are no different, and the biomechanical and bioelectrochemical fluxes they experience result in the production of an extra cellular matrix able to withstand variable and extreme mechanical loads. To confound this, cartilage does not have a blood supply and cells experience, in fact require, hypoxic and acidic conditions to fully function. These factors all play a role in the poor ability of cartilage to regenerate. The regenerative ability of cartilage to restore itself is of great interest in sports related injuries.The biological/biomechanical/bioelectrochemical aspects of cartilage and how these interact in disease and injury reveals intriguing and multidisciplinary avenues of research. The membrane is where the cell interacts with the environment and specialized structures link the extra cellular matrix to the cells cytoskeleton and nucleus influencing gene expression. Our investigations examine the growth of chondrocytes in 3D under hypoxic conditions, changes in gene expression of membrane associated proteins, particularly those responsible for ion movement across membranes, the ion and hemi channels.The bioelectrochemistry of chondrocytes is of huge importance and is the focus of our research through a grant from the NIAMS. A microfluidic approach enables dielectric measurements of cells to be made, with correlation to ion channel and matrix gene expression. The measured impedance is modeled using a combination of physical models, such as Cole-Cole, Constant Phase Angle, Maxwell Wagner mixture, double shell models. Subcellular dielectric parameters, such as conductance and capacitance of the cell membrane and nuclear envelope, and conductivity of the cytoplasm and nucleoplasm, are obtained as a result of dielectric modeling.
  • Contracts, Grants and Sponsored Research

    Stacey, M. W. "Intercelluler communication and chemoresistance in sarcomas" $18,000. Other. January 1, 2017 - December 31, 2017
    Osgood, C. J.; Stacey, M. W. "Electrochemotherapy and nanomedicine combine to enhance tumor cell death" $142,000. July, 2009 - June, 2010