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- Barbara Hargrave
- Associate Professor
- 202k Mills Godwin Bldg
-
Norfolk,
VA
23529
- 757-683-5867
- bhargrav@odu.edu
-
Education
- Hampton University,
- Degree: B.S.
- Bowman Gray School Of Medicine, Wake Forest University,
1985
- Major: Physiology/Pharmacology
- Degree: Ph. D.
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Articles
- Hargrave, B., Lattanzio, F. A., and Beebe, S. J. MDMA Activates Caspase and Generates Free Radicals in Heart Cells.
- Hargrave, B., and Beebe, S. J. PRP improves left ventricular function after myocardial infarction.
- Tiangco, D., Lattanzio, F. A., Halcomb, S., and Hargrave, B. MDMA Activates NFκB in H9C2 Cells Grown In Culture.
- Zhang, J., Blackmore, P. F., Hargrave, B., Xiao, S., Beebe, S. J., and Schoenbach, K. H. (2008). Nanosecond Pulse Electric Field (nanopulse): a Novel Non-ligand Agonist for Platelet Activation. Archives of Biochemistry and Biophysics, 471, (pp. 240-248).
- Osgood, C. J., Schoenbach, K. H., Hargrave, B., Joshi, R., Kolb, J. F., Nuccitelli, R., Pakhomov, A., Stacey, M. W., Swanson, R. J., White, J., Xiao, S., and Zhang, J. (2007). Bioelectric effects of intense nanosecond pulses. IEEE Transact Dielectrics Electrical Insul, 14, (pp. 1088-1109).
- Schoenbach, K. H., Hargrave, B., Joshi, R., Kolb, J. F., Osgood, C. J., Nuccitelli, R., Pakhomov, A., Swanson, R. J., Stacey, M., White, J. A., Xiao, S., Zhang, J., Beebe, S. J., Blackmore, P. F., and Buescher, E. S. (2007). Bioelectric Effects of Nanosecond Pulses. IEEE Trans. Diel. Electr. Insul., 14 (5), (pp. 1088-1109).
- Zhang, J., Blackmore, P. F., Hargrave, B., Xiao, S., Beebe, S. J., and Schoenbach, K. H. The Characteristics of Nanosecond Pulsed Electrical Field Stimulation on Platelet Aggregation in vitro.
- Tiangco, D. A., Lattanzio, F. A., Osgood, C. J., Beebe, S. J., Kerry, J. A., and Hargrave, B. (2005). 3,4-Methylendioxymethamphetamine activates nuclear factor-kappaB, increases intracellular calcium, and modulates gene transcription
in rat heart cells. Cardiovasc Toxicol, 5 (3), (pp. 301-310).
- Osgood, C. J., Lattanzio, F. A., Tiangco, D., Beebe, S., Kerry, J., and Hargrave, B. (2005). Cocaine increases intracellular calcium and reactive oxygen species, depolarizes, mitochondria and activates genes associated
with heart failure and remodeling. Cardiovasc Toxicol, 5 (4), (pp. 377-390).
- Hargrave, B., Tiangco, D., Lattanzio, F., and Beebe, S. J. (2003). Cocaine but not morphine causes the generation of reactive oxygen species and activation of NFκB in transiently co-transfected
heart and renal epithelial cells. Cardiovascular Toxicology, 3, (pp. 141-151).
- Hargrave, B., and Lattanzio, F. (2002). Cocaine activates the renin angiotensin system in pregnant rabbits and alters the response to ischemia. Cardiovascular Toxicology, 2, (pp. 91).
- Hargrave, B., and Castle, M. C. (1995). Effects of phenylephrine induced increase in arterial pressure and closure of the ductus arteriosus on the secretion of atrial
natriuretic peptide and renin in the ovine fetus. Life Sci, 57, (pp. 31).
- Hargrave, B., and Castle, M. C. (1995). Intrauterine exposure to cocaine increased plasma ANP but did not alter hypoxanthine concentrations in the sheep fetus. Life Sci, 56, (pp. 1689).
- Tkacs, N. C., Kim, M., Hargrave, B., and Ganong, W. F. (1990). Pharmacological evidence for involvement of the sympathetic nervous system in the increase in renin secretion produced by
a low sodium diet in rats. Life Sci, 47, (pp. 2317).
- Hargrave, B., Roman, C., Morville, P., and Heymann, M. (1990). Pulmonary vascular effects of exogenous atrial natriuretic peptide in sheep fetuses. Ped Res, 27, (pp. 140).
- Hargrave, B., Iwamoto, H. S., and Rudolph, A. M. (1989). Renal and cardiovascular effects of atrial natriuretic peptide in the sheep fetus. Pediatric Res, 26, (pp. 1).
- Hargrave, B., and Rose, J. C. (1986). By 95 days of gestation CRF increases plasma ACTH and cortisol in ovine fetuses. Am J Physiol, 250, (pp. E422).
- Hargrave, B., and Rose, J. C. (1985). By 94 days of gestation plasma cortisol increases block ACTH response of hypotension in lamb fetuses. Am J Physiol, 249, (pp. E350).
- Jones, C. M., Rose, J. C., Kelly, R. T., and Hargrave, B. (1985). Catecholamine responses in fetal lambs subjected to hemorrhage. Am J Obstet Gynecol, 151, (pp. 475).
- Rose, J. C., Hargrave, B., Dix, P. M., Meis, P. J., Lafave, M., and Torpe, B. (1985). Corticotrophin-releasing factor induced adrenocorticortropic hormone release in the sheep fetus: blockade by cortisol. Am J Obstet Gynecol, 151, (pp. 1128).
- Dix, P. M., Rose, J. C., Morris, M., Hargrave, B., and Meis, P. J. (1984). Cortisol infusion blocks adrenocorticortropic hormone but not vasopressin responses to hypotension in fetal lambs. Am J Obstet Gynecol, 148, (pp. 317).
- Rose, J. C., Jones, C. M., Kelly, R. T., Hargrave, B., and Meis, P. J. (1983). A vasopressin antagonist block norepinephrine and epinephrine responses to hemorrhage in the fetus. Endocrinol, 113, (pp. 2314).
- Kelly, R. T., Rose, J. C., Meis, P. J., Hargrave, B., and Morris, M. (1983). Vasopressin is important for restoring cardiovascular homeostasis in fetal lambs subjected to hemorrhage. Am J Obstet Gynecol, 146, (pp. 807).
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Presentations
- An Alternative To The use of Thrombin In The Activation of Platelet Gel: Nanosecond Pulsed Electric Fields (nsPEFs)
- Conference Name:
- Location: Greensboro, NC
- Date: September, 2009
- Authors/Presenters:
Hargrave, B.
- Alternative Method for Platelet Activation In the Preparation of Platelet Gel
- Conference Name:
- Location: Fort Myers, FL
- Date: 2008
- Authors/Presenters:
Hargrave, B.
- A Novel Approach for Wound Healing: Platelet Activation Using Nanosecond Pulse Electric Fields
- Conference Name: Old Dominion University
- Sponsoring Organization: Old Dominion University
- Location: Norfolk, VA
- Date: 2008
- Authors/Presenters:
Hargrave, B.
- Cocaine and the Cardiovascular System
- Conference Name: Old Dominion University
- Sponsoring Organization: Old Dominion University
- Location: Norfolk, VA
- Date: 2004
- Authors/Presenters:
Hargrave, B.
Tiangco, D.
Lattanzio, F.
- Cocaine and the Cardiovascular System Revisited: Still a Deadly Combination
- Sponsoring Organization: Department of Biological Sciences, Old Dominion University
- Location: Norfolk, VA
- Date: 2003
- Authors/Presenters:
Hargrave, B.
Tiangco, D.
Lattanzio, F.
- Cocaine Decreases Heart Function, Causes the Production of Reactive Oxygen Species, and Activates NFκB
- Conference Name:
- Location: Cleveland, OH
- Date: 2002
- Authors/Presenters:
Hargrave, B.
- Effect of Cocaine and Ecgonine Methyl Ester on Plasma Renin Activity and Heart Function in Pregnant and Nonpregnant Rabbits
and on NF-κB Rel Transcription Factors
- Conference Name: Experimental Biology
- Sponsoring Organization: Experimental Biology
- Location: Orlando, FL
- Date: 2001
- Authors/Presenters:
Hargrave, B.
- Effect of Cocaine and Ecgonine Methyl Ester on the Renin Angiotensin System and Cardiovascular Function in Pregnant, Nonpregnant,
and Male Rabbits
- Conference Name:
- Location: Orlando, FL
- Date: 2001
- Authors/Presenters:
Hargrave, B.
- Cocaine and the Cardiovascular System: A Deadly Combination
- Sponsoring Organization: Department of Biological Sciences, Old Dominion University
- Location: Norfolk, VA
- Date: 2000
- Authors/Presenters:
Hargrave, B.
- Cardiovascular Effects of Cocaine in the Pregnant Rabbit
- Sponsoring Organization: Old Dominion University
- Location: Norfolk, VA
- Date: 1999
- Authors/Presenters:
Jordan, T.
Hargrave, B.
Lattanzio, F.
- Ion Mobility Spectrometry of Animals Exposed to Physiologically Active Substances
- Conference Name: Gordon Research Conference
- Sponsoring Organization: Gordon Research Conference
- Location: Newport, RI
- Date: 1999
- Authors/Presenters:
Parson, H.
Chambliss, A.
Poziomek, E.
Hargrave, B.
- Ion Mobility Spectrometry with Samples of Biological Origin
- Conference Name: Virginia Academy of Sciences, George Mason University
- Sponsoring Organization: Virginia Academy of Sciences, George Mason University
- Location: Fairfax, VA
- Date: 1998
- Authors/Presenters:
Parson, H.
Chambliss, A.
Poziomek, e.
Hargrave, B.
- Ion Mobility Spectrometry with Animal Tissues and Plasma
- Conference Name: The American Chemical Society and Sigma Xi of Norfolk State University
- Sponsoring Organization: The American Chemical Society and Sigma Xi of Norfolk State University
- Location: Norfolk, VA
- Date: 1998
- Authors/Presenters:
Parson, H.
Chambliss, A.
Poziomek, E.
Hargrave, B.
- The Effect of Heroin on Plasma Renin Activity and ANP Secretion
- Conference Name: The American Chemical Society and Sigma Xi of Norfolk State University
- Sponsoring Organization: The American Chemical Society and Sigma Xi of Norfolk State University
- Location: Norfolk, VA
- Date: 1998
- Authors/Presenters:
Chambliss, A.
Parson, H.
Poziomek, E.
Hargrave, B.
- Effects of Increased Afterload on ANP Secretion in the Developing Ovine Fetus
- Sponsoring Organization: International Society for Heart Research
- Location: Burlington, VT
- Date: 1995
- Authors/Presenters:
Hargrave, B.
Castle, M.
- Renal and Pulmonary Effects of ANP in the Developing Ovine Fetus
- Sponsoring Organization: Department of Physiology, Howard University
- Location: Washington, D.C.
- Date: 1994
- Authors/Presenters:
Hargrave, B.
- Renal & Pulmonary Effects of ANP in the Developing Ovine Fetus
- Sponsoring Organization: Department of Pediatrics, Eastern Virginia Medical School
- Location: Norfolk, VA
- Date: 1993
- Authors/Presenters:
Hargrave, B.
- Mechanism of Action of Cocaine on the Cardiovascular System of the Developing Fetus
- Conference Name: Old Dominion University
- Sponsoring Organization: Old Dominion University
- Location: Norfolk, VA
- Date: 1992
- Authors/Presenters:
Hargrave, B.
- 1997: Hugo A. Owens Outstanding Faculty Award, Old Dominion University
- 1997: Outstanding Service Award, Old Dominion University
- 1986: President's Fellowship, University of California, San Francisco
- 1987: Neuroscience Travel Award
- 1987: Travel Award, American Physiological Society
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Contracts, Grants and Sponsored Research