Professor
Biological Sciences

Barbara Hargrave

757-683-5867

SUITE 300 RESEARCH PARK II 4211 MONARCH WAY
NORFOLK, 23529

B.S. in , Hampton University, ()

Ph.D. in Physiology/Pharmacology, Bowman Gray School Of Medicine, Wake Forest University, (1985)

Contracts, Grants and Sponsored Research

Hargrave, B. "Wound Healing Section, Center for Bioelectrics" $1,000,000. Federal. -
Osgood, C. J., Stacey, M. W., Elmustafa, A., Lai, N., Beebe, S. J., Hargrave, B., Zemlin, C. and Xu, X. "Addition of a micro-CT animal scanner to complement and expand current in vivo imaging capabilities" $423,850. Federal. -
Hargrave, B. "Platelet Activation Using Nanosecond Pulse Electric Fields" $80,000. Old Dominion University. January 1, 2007 -
Osgood, C. J. and Hargrave, B. "Development of a mouse model to investigate gender differences in drug-induced cardiovascular disease" $30,000. State. 2004 - 2005
Hargrave, B. "Jeffers Foundation Grant" $30,000. 2004 - 2004
Hargrave, B. ". 1997 - 1999
Hargrave, B. ". Federal. 1991 - 1993
Hargrave, B. "Summer Grant. Old Dominion University. 1990 - 1990

Expertise

Research
Use of Platelet Gel for the treatment of Cardiac Ischemia and Reperfusion Injury

Research Interests

Cardiovascular Physiology and Pharmacology

Articles

Hargrave, B., Varghese, F., Barabutis, N., Contravas, J. and Zemlin, C. (2016). Nanosecond Pulsed Platelet-Rich Plasma (nsPRP) Improves Mechanical and Electrical Cardiac Function Following Myocardial Reperfusion Injury. Physiological Reports.
Eldelblute, C., Pakhomova, O., Li, F., Hargrave, B. and Heller, L. (2015). Donor platelet plasma components inactivate sensitive and multidrug resistant Acinetobacter baumannii isolates. Pathog Dis 73.
Edelbute, C., Donate, A., Hargrave, B. and Heller, L. (2015). Human platelet gel supernatant inactivates opportunistic wound pathogens on skin. . Platelets 26.
Basu, G., Downey, H., Israel, A., Hargrave, B., Asmar, A., Guo, S. and Heller, R. (2014). Prevention of distal flap necrosis in a rat random flap model by gene electrotransfer delivering VEGF165 plasmid.. J Gene Medicine 16 , pp. 55-65.
Hargrave, B., Strange, Jr, R., Navaras, S., Stratton, M., Burcus, N., Murray, L., Lundbderg, C., Li, F. and Heller, R. (2014). Gene Electro transfer of plasmid encoding VEGF Improves pVEGF expression and Perfusion In the Ischemic Swine Heart. PLsoOne.
Hargrave, B., Downey, H., Strange, Jr, R., Murray, L., Cinnamond, C., Lundberg, C., Israel, A., Chen, Y. and Marshall, W. (2012). Electroporation-mediated gene transfer directly to the swine heart.. Gene Therapy 20.
Zhang, J., Blackmore, P. F., Hargrave, B., Xiao, S., Beebe, S. J. and Schoenbach, K. H. (2008). Nanosecond Pulse Electric Field (nanopulse): a Novel Non-ligand Agonist for Platelet Activation. Archives of Biochemistry and Biophysics 471 , pp. 240-248.
Osgood, C. J., Schoenbach, K. H., Hargrave, B., Joshi, R., Kolb, J. F., Nuccitelli, R., Pakhomov, A., Stacey, M. W., Swanson, R. J., White, J., Xiao, S. and Zhang, J. (2007). Bioelectric effects of intense nanosecond pulses. IEEE Transact Dielectrics Electrical Insul 14 , pp. 1088-1109.
Schoenbach, K. H., Hargrave, B., Joshi, R., Kolb, J. F., Osgood, C. J., Nuccitelli, R., Pakhomov, A., Swanson, R. J., Stacey, M., White, J. A., Xiao, S., Zhang, J., Beebe, S. J., Blackmore, P. F. and Buescher, E. S. (2007). Bioelectric Effects of Nanosecond Pulses. IEEE Trans. Diel. Electr. Insul. 14 (5) , pp. 1088-1109.
Tiangco, D. A., Lattanzio, F. A., Osgood, C. J., Beebe, S. J., Kerry, J. A. and Hargrave, B. (2005). 3,4-Methylendioxymethamphetamine activates nuclear factor-kappaB, increases intracellular calcium, and modulates gene transcription in rat heart cells. Cardiovasc Toxicol 5 (3) , pp. 301-310.
Osgood, C. J., Lattanzio, F. A., Tiangco, D., Beebe, S., Kerry, J. and Hargrave, B. (2005). Cocaine increases intracellular calcium and reactive oxygen species, depolarizes, mitochondria and activates genes associated with heart failure and remodeling. Cardiovasc Toxicol 5 (4) , pp. 377-390.
Hargrave, B., Tiangco, D., Lattanzio, F. and Beebe, S. J. (2003). Cocaine but not morphine causes the generation of reactive oxygen species and activation of NFκB in transiently co-transfected heart and renal epithelial cells. Cardiovascular Toxicology 3 , pp. 141-151.
Hargrave, B. and Lattanzio, F. (2002). Cocaine activates the renin angiotensin system in pregnant rabbits and alters the response to ischemia. Cardiovascular Toxicology 2 , pp. 91.
Hargrave, B. and Castle, M. C. (1995). Effects of phenylephrine induced increase in arterial pressure and closure of the ductus arteriosus on the secretion of atrial natriuretic peptide and renin in the ovine fetus. Life Sci 57 , pp. 31.
Hargrave, B. and Castle, M. C. (1995). Intrauterine exposure to cocaine increased plasma ANP but did not alter hypoxanthine concentrations in the sheep fetus. Life Sci 56 , pp. 1689.
Tkacs, N. C., Kim, M., Hargrave, B. and Ganong, W. F. (1990). Pharmacological evidence for involvement of the sympathetic nervous system in the increase in renin secretion produced by a low sodium diet in rats. Life Sci 47 , pp. 2317.
Hargrave, B., Roman, C., Morville, P. and Heymann, M. (1990). Pulmonary vascular effects of exogenous atrial natriuretic peptide in sheep fetuses. Ped Res 27 , pp. 140.
Hargrave, B., Iwamoto, H. S. and Rudolph, A. M. (1989). Renal and cardiovascular effects of atrial natriuretic peptide in the sheep fetus. Pediatric Res 26 , pp. 1.
Hargrave, B. and Rose, J. C. (1986). By 95 days of gestation CRF increases plasma ACTH and cortisol in ovine fetuses. Am J Physiol 250 , pp. E422.
Hargrave, B. and Rose, J. C. (1985). By 94 days of gestation plasma cortisol increases block ACTH response of hypotension in lamb fetuses. Am J Physiol 249 , pp. E350.
Jones, C. M., Rose, J. C., Kelly, R. T. and Hargrave, B. (1985). Catecholamine responses in fetal lambs subjected to hemorrhage. Am J Obstet Gynecol 151 , pp. 475.
Rose, J. C., Hargrave, B., Dix, P. M., Meis, P. J., Lafave, M. and Torpe, B. (1985). Corticotrophin-releasing factor induced adrenocorticortropic hormone release in the sheep fetus: blockade by cortisol. Am J Obstet Gynecol 151 , pp. 1128.
Dix, P. M ., Rose, J. C., Morris, M., Hargrave, B. and Meis, P. J. (1984). Cortisol infusion blocks adrenocorticortropic hormone but not vasopressin responses to hypotension in fetal lambs. Am J Obstet Gynecol 148 , pp. 317.
Rose, J. C., Jones, C. M., Kelly, R. T., Hargrave, B. and Meis, P. J. (1983). A vasopressin antagonist block norepinephrine and epinephrine responses to hemorrhage in the fetus. Endocrinol 113 , pp. 2314.
Kelly, R. T., Rose, J. C., Meis, P. J., Hargrave, B. and Morris, M. (1983). Vasopressin is important for restoring cardiovascular homeostasis in fetal lambs subjected to hemorrhage. Am J Obstet Gynecol 146 , pp. 807.

Presentations

Hargrave, B. (September , 2009). An Alternative To The use of Thrombin In The Activation of Platelet Gel: Nanosecond Pulsed Electric Fields (nsPEFs) Perfusionist Society Meeting Greensboro, NC.
Hargrave, B. ( 2008). Alternative Method for Platelet Activation In the Preparation of Platelet Gel International Platelet Gel and Stem Cell Symposium Fort Myers, FL.
Hargrave, B. ( 2008). A Novel Approach for Wound Healing: Platelet Activation Using Nanosecond Pulse Electric Fields Molecular Medicine Seminar Series Norfolk, VA.
Hargrave, B., Tiangco, D. and Lattanzio, F. ( 2004). Cocaine and the Cardiovascular System Research Day Norfolk, VA.
Hargrave, B., Tiangco, D. and Lattanzio, F. ( 2003). Cocaine and the Cardiovascular System Revisited: Still a Deadly Combination Norfolk, VA.
Hargrave, B. ( 2002). Cocaine Decreases Heart Function, Causes the Production of Reactive Oxygen Species, and Activates NFκB Heart Failure and Circulatory Summit I Cleveland, OH.
Hargrave, B. ( 2001). Effect of Cocaine and Ecgonine Methyl Ester on Plasma Renin Activity and Heart Function in Pregnant and Nonpregnant Rabbits and on NF-κB Rel Transcription Factors Annual Meeting Orlando, FL.
Hargrave, B. ( 2001). Effect of Cocaine and Ecgonine Methyl Ester on the Renin Angiotensin System and Cardiovascular Function in Pregnant, Nonpregnant, and Male Rabbits FSEBE Meeting Orlando, FL.
Hargrave, B. ( 2000). Cocaine and the Cardiovascular System: A Deadly Combination Norfolk, VA.
Jordan, T., Hargrave, B. and Lattanzio, F. ( 1999). Cardiovascular Effects of Cocaine in the Pregnant Rabbit Norfolk, VA.
Parson, H., Chambliss, A., Poziomek, E. and Hargrave, B. ( 1999). Ion Mobility Spectrometry of Animals Exposed to Physiologically Active Substances Chemical and Biological Detection Poster Presentation Session Newport, RI.
Parson, H., Chambliss, A., Poziomek, e. and Hargrave, B. ( 1998). Ion Mobility Spectrometry with Samples of Biological Origin 76th Annual Meeting Fairfax, VA.
Parson, H., Chambliss, A., Poziomek, E. and Hargrave, B. ( 1998). Ion Mobility Spectrometry with Animal Tissues and Plasma Multi-Discipline Student Research Poster Session Norfolk, VA.
Chambliss, A., Parson, H., Poziomek, E. and Hargrave, B. ( 1998). The Effect of Heroin on Plasma Renin Activity and ANP Secretion Multi-Discipline Student Research Poster Session Norfolk, VA.
Hargrave, B. and Castle, M. ( 1995). Effects of Increased Afterload on ANP Secretion in the Developing Ovine Fetus Burlington, VT.
Hargrave, B. ( 1994). Renal and Pulmonary Effects of ANP in the Developing Ovine Fetus Washington, D.C..
Hargrave, B. ( 1993). Renal & Pulmonary Effects of ANP in the Developing Ovine Fetus Norfolk, VA.
Hargrave, B. ( 1992). Mechanism of Action of Cocaine on the Cardiovascular System of the Developing Fetus Research in Progress II: Women's Issues Norfolk, VA.
  • 1997: Hugo A. Owens Outstanding Faculty Award, Old Dominion University
  • 1997: Outstanding Service Award, Old Dominion University
  • 1987: Neuroscience Travel Award,
  • 1987: Travel Award, American Physiological Society
  • 1986: President's Fellowship, University of California, San Francisco

Organizational Chart