Lisa Shollenberger

Ph.D. in Biochemistry & Molecular Genetics, University of Pittsburgh, (2009)

Expertise

Research Interests

The long term goal of my research program is to produce more effective vaccines, specifically designed with target populations in mind, by understanding the mechanisms of vaccine efficacy in the context of confounding factors. The objectives of my funded research program are to improve vaccine efficacy for high-risk and immune-suppressed populations, such as the elderly and helminth-infected, by: (1) interrogating the host-parasite-vaccine tripartite relationship, (2) understanding the contribution of the microbiome to vaccine efficacy, and (3) modifying delivery of vaccines and the way in which vaccines interact with the immune system.

Articles

Grenfell, R. F.., Shollenberger, L., Samli, E. Farah. and Harn, D. A.. (2015). Vaccine Self-Assembling Immune Matrix Is a New Delivery Platform That Enhances Immune Responses to Recombinant HBsAg in Mice. Clinical and Vaccine Immunology 22 (3) , pp. 336-343.

Da'Dara, A., Li, C., Yu, X., Zheng, M., Zhou, J., Shollenberger, L., Li, Y. and Harn, D. (2019). Prime-boost vaccine regimen for SjTPI and SjC23 schistosome vaccines, increases efficacy in water buffalo in a field trial in China. Frontiers in immunology 10 , pp. 284.

Shollenberger, L., Bui, C., Paterson, Y., Allen, K. and Harn, D. (2013). Successful vaccination of immune suppressed recipients using Listeria vector HIV-1 vaccines in helminth infected mice. Vaccine 31 (16) , pp. 2050-2056.

Shollenberger, L., Bui, C. T.., Paterson, Y., Nyhoff, L. and Harn, D. A.. (2013). HIV-1 vaccine-specific responses induced by Listeria vector vaccines are maintained in mice subsequently infected with a model helminth parasite, Schistosoma mansoni. Vaccine 31 (48) , pp. 5651-5658.

Liu, F., Shollenberger, L. and Huang, L. (2004). Non-immunostimulatory nonviral vectors. The FASEB Journal 18 (14) , pp. 1779-1781.

Liu, F., Conwell, C. C.., Yuan, X., Shollenberger, L. and Huang, L. (2007). Novel nonviral vectors target cellular signaling pathways: Regulated gene expression and reduced toxicity. Journal of Pharmacology and Experimental Therapeutics 321 (2) , pp. 777-783.

Liu, F., Shollenberger, L., Conwell, C. C.., Yuan, X. and Huang, L. (2007). Mechanism of naked DNA clearance after intravenous injection. The Journal of Gene Medicine 9 (7) , pp. 613-619.

Liu, F., Heston, S., Shollenberger, L., Sun, B., Mickle, M., Lovell, M. and Huang, L. (2006). Mechanism of in vivo DNA transport into cells by electroporation: electrophoresis across the plasma membrane may not be involved. The Journal of Gene Medicine 8 (3) , pp. 353-361.

Liu, F., Sag, D., Wang, J., Shollenberger, L., Niu, F., Yuan, X., Li, S., Thompson, M. and Monahan, P. (2007). Sine-wave current for efficient and safe in vivo gene transfer. Molecular Therapy 15 (10) , pp. 1842-1847.

Liao, C. and Shollenberger, L. (2003). Detection of Salmonella by indicator agar media and PCR as affected by alfalfa seed homogenates and native bacteria. Letters in Applied Microbiology 36 (3) , pp. 152-156.

Liao, C. and Shollenberger, L. (2003). Survivability and long-term preservation of bacteria in water and in phosphate-buffered saline. Letters in Applied Microbiology 37 (1) , pp. 45-50.

LIAO, C. H.., Shollenberger, L. and PHILLIPS, J. G.. (2003). Lethal and Sublethal Action of Acetic Acid on Salmonella In Vitro and on Cut Surfaces of Apple Slices. Journal of Food Science 68 (9) , pp. 2793-2798.

Liao, C. and Shollenberger, L. (2004). Enumeration, Resuscitation, and Infectivity of the Sublethally Injured Erwinia Cells Induced by Mild Acid Treatment. Phytopathology 94 (1) , pp. 76-81.

Silva-Moraes, V., Shollenberger, L., Siqueira, L. Maria Vidal., Castro-Borges, W., Harn, D. A., Rabello, A. Lucia Teles., Coelho, P. Marcos Zech. and others (2019). Diagnosis of Schistosoma mansoni infections: what are the choices in Brazilian low-endemic areas?. Mem\'orias do Instituto Oswaldo Cruz 114.

Williams, G., Li, Y., Gray, D. J., Zhao, Z., Harn, D., Shollenberger, L., Li, S., Yu, X., Feng, Z., Guo, J. and others (2019). Field testing integrated interventions for schistosomiasis elimination in the People’s Republic of China: Outcomes of a multifactorial cluster-randomised controlled trial. Frontiers in immunology 10 , pp. 645.

Silva-Moraes, V., Shollenberger, L., Castro-Borges, W., Rabello, A. Lucia Teles., Harn, D. A., Medeiros, L. Carolina Soares., de Jesus Jeremias, W., Siqueira, L. Maria Vidal., Pereira, C. Stephane Salviano., Pedrosa, M. Luysa Camargos. and others (2019). Serological proteomic screening and evaluation of a recombinant egg antigen for the diagnosis of low-intensity Schistosoma mansoni infections in endemic area in Brazil. PLoS neglected tropical diseases 13 (3) , pp. e0006974.

Bui, C. T.., Shollenberger, L., Paterson, Y. and Harn, D. A.. (2015). Schistosoma mansoni Soluble Egg Antigens Enhance T Cell Responses to a Newly Identified HIV-1 Gag H-2(b) Epitope. Clinical and Vaccine Immunology 22 (2) , pp. 193-199.

Bui, C. T.., Shollenberger, L., Paterson, Y. and Harn, D. A.. (2014). Schistosoma mansoni Soluble Egg Antigens Enhance Listeria monocytogenes Vector HIV-1 Vaccine Induction of Cytotoxic T Cells. Clinical and Vaccine Immunology 21 (9) , pp. 1232-1239.

Book Chapters

Shollenberger, L. and Huang, L. (2006). Liposome-Polycation-DNA Liposome Technology, Volume II (pp. 245-252) Informa Healthcare.

Conference Proceeding

Shollenberger, L., Hentze, H. and Ibsen, E. (2019). The “Crisis of Reproducibility” of Animal Studies: Causes and Solutions American Association of Immunologists.

Shollenberger, L., Dixon, J., Mendoza, A., Shiau, J., Punde, N., Pathak, A., Sarr, D., Murdock, C., Champagne, D., Angov, E. and others (2018). Immunogenicity and Efficacy of Malarial CelTOS and CSP Vaccine Antigens Administered with Gel-Depot Adjuvant American Journal of Tropical Medicine and Hygiene (pp. 135--135).

Silva-Moraes, V., Coelho, P. M.., Harn, D. A.., Couto, F. F.., Borges, W. C.., Grenfell, R. F.., Rabello, Ana Lucia T. and Shollenberger, L. (2017). An egg protein from Schistosoma mansoni is promising for development of high-specificity diagnostics in the era of intensified control (pp. 384-384) American Journal of Tropical Medicine and Hygeine.

Harn, D., Ramadhin, J., Meagher, R., Ambati, S., Filipov, N., Shollenberger, L. and Norberg, T. (2017). LNFPIII-Dex conjugates function in vivo to normalize metabolic function in High-Fat Diet Obese mice (pp. 1190-1191) Glycobiology.

Grenfell e Queiroz, Rafaella Fortini, Cruz, R., Pedrosa, M. Luysa., Oliveira, M., Jeremias, W., Assis, J., Coutinho, L., Taboada, D., Moraes, V., McEwen, L., Harn, D. and Coelho, P. Marcos. (2017). Overcoming challenges in the diagnosis of Schistosoma mansoni infections using POC tests, recombinant protein and monoclonal antibody technology Faseb Journal .

Shollenberger, L. and Harn, D. A.. (2017). Vaccine self-assembling immune matrix is a non-viral delivery platform that improves overall vaccine performance while maintaining safety and stability Journal of Immunology.

Shollenberger, L., Grenfell, R., Samli, E. and Harn, D. (2015). Enhancing immunogenicity of recombinant protein vaccines in mice with vaccine self-assembling immune matrix, a non-viral delivery platform Journal of Immunology.

Shollenberger, L., Grenfell, R., Samli, E. Farah. and Harn, D. (2014). Vaccine self-assembling immune matrix (VacSIM) is a non-viral delivery platform that augments responses to recombinant protein vaccines Journal of Immunology.

Samli, E. Farah., Shollenberger, L. and Harn, D. (2014). VacSIM (TM) - a new delivery method increases influenza vaccine efficacy Journal of Immunology.

McEwen, L., Bui, C., Paterson, Y. and Harn, D. (2012). Driving HIV-specific vaccine responses in immune suppressed recipients Journal of Immunology.

McEwen, L., Bui, C., Paterson, Y. and Harn, D. (2011). Driving HIV-1 specific responses in immune suppressed recipients: Listeria as a vaccine vector Journal of Immunology.

Queiroz, R., Allen, K., McEwen, L., Ring, J. and Harn, D. (2011). New vaccination delivery regimen drives enhanced, vaccine-specific immune responses. Journal of Immunology.

Shollenberger, L. and Huang, L. (2006). Interaction of LPD Nanoparticles with Dendritic Cells (pp. S412-S412) Molecular Therapy.

Liu, F., Shollenberger, L., Conwell, C. C.., Yuan, X. and Huang, L. (2006). Mechanism of Naked DNA Clearance after Intravenous Injection (pp. S412-S413) Molecular Therapy.

Presentations

Shollenberger, L. (May 21, 2019). Overcoming Vaccine Failure Keynote/Plenary Address Research Symposium and 78th Annual Meeting .

Shollenberger, L. M., Hentze, H. and Ibsen, E. (May 11, 2019). The “Crisis of Reproducibility” of Animal Studies: Causes and Solutions Poster Immunology 2019 San Diego, CA, USA.

Shollenberger, L. (March 3, 2019). Keynote/Plenary Address Induction Ceremony .

Shollenberger, L. M., Dixon, J., Mendoza, A., Shiau, J., Punde, N., Pathak, A., Sarr, D., Murdock, C., Champagne, D., Angov, E. and Harn, D. A. (October 29, 2018). Immunogenicity and Efficacy of Malarial CelTOS and CSP Vaccine Antigens Administered with Gel-Depot Adjuvant Poster ASTMH18 New Orleans, LA, USA.