Lesley Greene
CHEMISTRY BUILDING 4501 ELKHORN AVE
NORFOLK, 23529
Ph.D. in Biochemistry, University of Miami, (1998)
B.S. in Microbiology, University of Miami, (1991)
Contracts, Grants and Sponsored Research
- Xu, L. D., Watson, S. R., Gillis, C., Li, L. X., He, W. and Greene, L. Hope. "An Online Tacit Knowledge-Transferring Tool for Novice Science Teachers Who Teach Students with Disabilities" $200,000. Federal. -
- Greene, L. Hope. "Exploratory Look into the Future: Investigation Adaptation" $1,250. July 1, 2017 - June 30, 2018
- Greene, L. Hope. "Exploratory look into the future: Investigating adaption and evolution of Synechococcus in response to high CO2 at the genomic-level" $2,500. State. July 2017 -
- Greene, L. Hope. "PURS" $10,000. 2016 -
- Greene, L. Hope. "Vas Chrctztn Wheat Lipcln Vari" $1,250. July 1, 2014 - August 30, 2015
- Greene, L. Hope. "Jeffress Grant" $20,000. State. 2009 - 2010
- Greene, L. Hope. "SEECR Grant" $17,000. Old Dominion University. May 2009 - August 2009
- Greene, L. Hope. "Jeffress Grant" $22,000. State. 2008 - 2008
- Greene, L. Hope., Luo, L., Pothen, A., Osgood, C. J. and Hatcher, P. G. "Elucidation of protein structure networks and beyond" $80,000. Old Dominion University. January 01, 2008 - June 30, 2008
- Greene, L. Hope. "Multidisciplinary Grant" $80,000. Old Dominion University. January 2008 - May 2008
- Greene, L. Hope. "Faculty Research Fellowship" $7,000. Old Dominion University. May 2007 - August 2007
- Greene, L. Hope. "Engineering and Physical Sciences Research Council Grant (U.K.). 2002 - 2005
- Greene, L. Hope. "Biotechnology and Biological Sciences Research Council Grant (U.K.)" $198,379. Other. 2002 - 2004
- Greene, L. Hope. "Lockey Bequest Travel Awards. 2002 - 2002
- Greene, L. Hope. "International Research Fellows Award" $117,000. Federal. 2000 - 2002
- Greene, L. Hope. "Lockey Bequest Travel Awards. 2000 - 2000
Expertise
Research Interests
1. Protein Chemistry2. Molecular Biology and Genetic Engineering3. Bioinformatics and Genomics4. Protein Evolution5. Biophysics: Multidimensional heteronuclear NMR, Real-time 1D NMR & Photo-CIDNP, Circular dichroism & Fluorescence spectroscopy (equilibrium & stopped flow); Quenched flow HX.
Articles
- Collins, J. C., Bedford, J. T. and Greene, L. Hope. (2016). Elucidating the Key Determinants of Structure, Folding, and Stability for the (4 beta-alpha) Conformation of the B1 Domain of Protein G Using Bioinformatics Approaches. IEEE transactions on nanobioscience.
- Greene, L. Hope., Li , H., Zhong, J., Zhao, G. and Wilson, K. (2012). Folding of an all-helical Greek-key protein monitored by quenched-flow hydrogen-deuterium exchange and NMR spectroscopy. European biophysics journal (EBJ) 41 (1) , pp. 41-51.
- Greene, L. Hope. and Grant, T. (2012). Protein folding by 'levels of separation': a hypothesis. FEBS letters 586 (7) , pp. 962-6.
- Collins, J. C. and Greene, L. Hope. (2012). Biophysical analysis of the transition of an all α-helical Greek-key protein into amyloid fibrils composed of β-sheet structure. Protein and peptide letters 19 (9) , pp. 982-90.
- Greene, L. Hope. (2012). Protein structure networks. Briefings in functional genomics 11 (6) , pp. 469-78.
- Li, H. and Greene, L. Hope. (2010). Sequence and structural analysis of the chitinase insertion domain reveals two conserved motifs involved in chitin-binding. PLoS One 13 , pp. e8654.
- Li, H., Wojtaszek, J. and Greene, L. Hope. (2009). Analysis of conservation in the Fas-associated death domain protein and the importance of conserved tryptophans in structure, stability, and folding. Biochmica et Biophysica Acta - Proteins & Proteomics 1794 , pp. 583-593.
- Higman, V. A., Rosner, H. I., Ugolini, R., Greene, L. Hope., Redfield, C. and Smith, L. J. (2009). Probing the urea dependence of nonrandom interactions in denatured human α-lactalbumin. J. Biomolecular NMR 45 , pp. 121-131.
- Cuff, A., Redfern, O. C., Greene, L. Hope., Sillitoe, I., Lewis, T., Dibley, M., Reid, A., Pearl, F., Dallman, T., Todd, A., Garratt, R., Thornton, J. and Orengo, C. (2009). The CATH hierarchy revisited - structural divergence in domain superfamilies and the continuity of fold space. Structure 17 , pp. 1051-1062.
- Greene, L. Hope., Lewis, T. E., Addou, S., Cuff, A., Dallman, T., Dibley, M., Redfern, O., Pearl, F., Nambudiry, R., Reid, A., Sillitoe, L., Yeats, C., Thornton, J. M. and Orengo, C. A. (2007). The CATh domain structure database: new protocols and classification levels give a more comprehensive resource for exploring evolution. Nucleic Acids Research 35 , pp. D291-D297.
- Greene, L. Hope., Wijesinha-Bettoni, R. and Redfield, C. (2006). Characterization of the molten globule of human-serum retinol-binding protein by NMR spectroscopy. Biochemistry 45 , pp. 9475-9484.
- Higman, V. A. and Greene, L. Hope. (2006). Elucidation of conserved long-range interaction networks in proteins and their significance in determining protein topology. Physica A , pp. 595-606.
- Paci, E., Greene, L. Hope., Jones, R. M. and Smith, L. J. (2005). Characterization of the molten globule state of retinol-binding protein using a molecular dynamics simulation approach. FEBS J 272 , pp. 4826-4838.
- Greene, L. Hope. and Higman, V. A. (2005). Conserved networks and the determinants of protein topology. FEBS J 272 , pp. Suppl. 1.
- Neerathilingam, M., Greene, L. Hope., Colebrooke, S. A., Campbell, I. D. and Staunton, D. (2005). Quantitation of protein expression in a cell-free system: Efficient detection of yields and 19F NMR to identify folded protein. J Biomolecular NMR 31 , pp. 11-19.
- Greene, L. Hope., Hamada, D., Eyles, S. J. and Brew, K. (2003). Conserved signature proposed for folding in the lipocalin superfamily. FEBS letters 553 (1-2) , pp. 39-44.
- Greene, L. Hope. and Higman, V. A. (2003). Uncovering network systems within protein structures. Journal of molecular biology 334 (4) , pp. 781-91.
- McCammon, M. G., Scott, D. J., Keetch, C. A., Greene, L. Hope., Purkey, H. E., Petrassi, H. M., Kelly, J. and Robinson, C. V. (2002). Screening transthyretin amyloid fibril inhibitors: characterization of novel multiprotein, multiligand complexes by mass spectrometry. Structure (London, England : 1993) 10 (6) , pp. 851-63.
- Greene, L. Hope., Chrysina, E. D., Irons, L. I., Papageorgiou, A. C., Acharya, K. R. and Brew, K. (2001). Role of conserved residues in structure and stability: tryptophans of human serum retinol-binding protein, a model for the lipocalin superfamily. Protein science : a publication of the Protein Society 10 (11) , pp. 2301-16.
- Greene, L. Hope., Grobler, J. A., Malinovskii, V. A., Tian, J., Acharya, K. R. and Brew, K. (1999). Stability, activity and flexibility in alpha-lactalbumin. Protein engineering 12 (7) , pp. 581-7.
Book Chapters
- Collins, J. and Greene, L. Hope. (2013). Conversion of all α-helical proteins into an alternative β-amyloid conformation Bio-nanoimaging – Protein Misfolding and Aggregation. (pp. 485-501) Academic Press.
- Gaforina, L., Sanchez, D., Greene, L. Hope. and Flower, D. R. (2006). The lipocalin protein family: Protein sequence and structure Lipocalins Georgetown, TX: Landes Biosciences and Eurekha.com.
Presentations
- Barnes, C., Greene, L. Hope. and Lee, J. (March , 2019). Assessing the stability and expression of transgenes in genetically engineered cyanobacteria for biofuel production Poster 257th American Chemical Society Orlando, FL.
- Sacko, O., Barnes, C., Greene, L. Hope. and Lee, J. (March , 2019). Survivability of genetically engineered Thermosynechococcus elongatus BP1 in different temperature conditions Poster 257th American Chemical Society Orlando, FL.
- Haratipour, Z., Poutsma, J. and Greene, L. (March , 2019). Conserved long-range interaction networks, energetics and the determinants of protein topology Oral Presentation 257th American Chemical Society National Meeting Orlando, FL.
- Bedford, J., Poutsma, J. and Greene, L. (May , 2018). Persistence of key long-range interactions during GB1 unfolding simulations Oral Presentation 96th Annual Meeting of the Virginia Academy of Science .
- Haratipour, Z. (March , 2018). Characterization of long-range interaction networks in proteins using key network principles Oral Presentation 255th American Chemical Society National Meeting .
- Beford, J., Greene, L. and Poutsma, J. (March , 2018). Computational exploration of the β-grasp fold for structure, function, and stability Oral Presentation 255th American Chemical Society National Meeting .
- Haratipour, Z. and Greene, L. (May , 2017). The significance of the conserved long-ranged interaction networks in determining protein topology Oral Presentation The 95th Virginia Academy of Sciences Annual Meeting .
- Greene, L. Hope. (November , 2010). Greensboro, NC.
- Greene, L. Hope. (June , 2010). International Conference on Cold Plasma in Medicine Norfolk, VA.
- Greene, L. Hope. (August , 2009). 238th American Chemical Society National Conference Washington, DC.
- Greene, L. Hope. (April , 2009). Conserved Protein Structure Networks Rock Hill, SC.
- Greene, L. Hope. (October , 2008). Computational approaches to study protein structure and folding Hampton, VA.
- Greene, L. Hope. (October , 2008). Conserved Protein Structure Networks Shippensburg, PA.
- Greene, L. Hope. (October , 2008). Protein structure networks and the fold continuum Ashland, VA.
- Greene, L. Hope. (April , 2008). Computational approaches to study protein structure and folding Norfolk, VA.
- Greene, L. Hope. (March , 2008). Computational approaches to study protein structure and folding Lexington, VA.
- Greene, L. Hope. (April , 2007). Computational approaches to study protein structure and folding Fairfax, VA.
- Greene, L. Hope. (April , 2007). Computational approaches to study protein structure and folding Norfolk, VA.
- Greene, L. Hope. (September , 2006). 'Bioinformatics to Proteomics' Course London, UK.
- Greene, L. Hope. (July , 2005). 30th FEBS Congress and 9th IUBMB Conference on Proteins Budapest, Hungary.
- 2017: John R. Broderick Diversity Champion Award, ODU President
- 2010: Most Inspiring Faculty Mentor, Department of Chemistry and Biochemistry (Top Graduating Biochemistry Senior)
- 2009: Most Inspiring Faculty Mentor, Department of Chemistry and Biochemistry (Top Graduating Biochemistry Senior)